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Saffron Walden

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Our Discovery DMPK (Drug Metabolism and Pharmacokinetics) department in the UK is a multidisciplinary team led by Pharma experienced drug discovery scientists.  Our aim is to provide expert DMPK strategy and support to projects in an efficient and flexible manner.  We value the contributions of each and every team member from gap year students to seasoned DMPK Discipline leads and everything in between (schedulers, template builders, process improvers, in vitro ADME data generation and interpretation, bioanalytical data, PK parameter determination, modelling and simulation, human dose predictions).

We have a strong team culture where the collective team share a common goal and take ownership of the day to day and future strategy whilst making the most of individual strengths.  We think in solutions whether that is troubleshooting the instruments in the lab or working out what we need to do to understand the PK/PD relationship for a specific project. 


We make a real impact on a range of integrated drug discovery projects from different therapeutic areas (CNS, oncology, respiratory…), target classes (ion channels, enzymes…) and modalities (small molecules, protein degraders…).  If you want to experience a variety of challenges and learnings there is no better place to be.

Our CADD & Predictive Sciences team are core members of drug discovery optimisation programs within Charles River.  Applying computational modelling expertise in partnership with medicinal chemistry and structural biology colleagues makes a real impact on the progression of drug discovery projects from hit identification through to candidate nomination.

By joining our CADD & Predictive Sciences team you will have the opportunity to work with a diverse range of organisations across the globe, from charitable organisations and academic groups to biotech and major pharma, helping to bring much needed medicines to patients faster.

You will work on a wide range of drug discovery projects across different therapeutic areas and target classes at all stages of the drug discovery process, and you will have the opportunity to work with world class scientists in different disciplines from across the wider Charles River organisation.  With a strong culture of personal development, we will support you every step of the way as you progress your career at Charles River.

We believe that no other drug discovery organisation can offer such a rich and diverse array of development opportunities as you will find at Charles River.

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